Clinical Interests

     Psychopharmacology
      Mood Disorders
      Bipolar Disorder (Manic-Depression)
      Depressive Disorders

Research Interests

     Our research programs focus on the development of improved therapeutics for primary mood disorders, including depression and bipolar disorders. Specific research interests include psychopharmacology, omega-3 fatty acids, novel drug delivery systems and devices for the treatment of mood disorders.  

Academic Background and Distinctions

     Dr. Marangell graduated from Baylor College of Medicine and then completed her internship, residency, and chief residency at Albert Einstein College of Medicine/Montefiore Medical Center in New York. She then spent three years at the National Institute of Mental Health, as a Fellow and Senior Staff Fellow, specializing in clinical research, psychopharmacology and mood disorders. Dr. Marangell joined the faculty of Baylor College of Medicine in 1994 where she currently holds the positions of Associate Professor of Psychiatry, Director of Clinical Psychopharmacology and Director of Mood Disorders Research in the Department of Psychiatry. She has received numerous awards including the Laughlin Fellowship of the American College of Psychiatrists and the Young Investigators Award from the National Alliance for Research in Schizophrenia and Affective Disorders and most recently the Annual Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill. She lectures nationally and internationally as an expert on topics related to psychopharmacology and mood disorders. Her book, Concise Guide to Psychopharmacology (second edition) is available through the American Psychiatric Press Inc.. 

Selected Publications  

• Marangell LB, Rush AJ, George MS, Georges D, Sackeim HA, Johnson CR, Husain MM, Nahas Z, Lisanby SH. Vagus Nerve Stimulation (VNS) for Major Depressive Episodes: One Year Outcomes.  Biol Psychiatry, 2002; 51: 280-287.
• Marangell LB, Rush AJ, George MS, Georges D, Sackeim HA. A review of vagus nerve stimulation for Treatment-Resistant Depression.  Epilepsy & Behavior, 2001; 2: S6-S10.
• Marangell LB. Switching Antidepressants for Treatment-Resistant Major Depression. J Clin Psychiatry, 2001; 62 Suppl 18:12-17.  
• Marangell LB. Augmentation of standard depression therapy. Clin Ther 2000;22 Suppl A:A25-38; discussion A39-41.
  
• George MS, Sackeim HA, Rush AJ, Marangell LB, Nahas Z, Husain MM, Lisanby S, Burt T, Goldman J, Ballenger JC. Vagus nerve stimulation: a new tool for brain research and therapy. Biol Psychiatry 
  2000 Feb 15;47(4):287-95.     
  
• Rush AJ, George MS, Sackeim HA, Marangell LB, Husain MM, Giller C, Nahas Z, Haines S, Simpson RK Jr, Goodman R. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry 2000 Feb 15;47(4):276-86.     
  
• Stoll AL, Locke CA, Marangell LB, Severus E. Omega-3 fatty acids and bipolar disorder: A review. Prostaglandins, Leukotriens and Essential Fatty Acids 1999 60 (5&6), 329-337 
  
• Sullivan GM, Hatterer JA, Herbert J, Chen X, Roose SP, Attia E, Mann JJ, Marangell LB, Goetz RR, 
  Gorman JM. Low levels of transthyretin in the CSF of depressed patients. Am J Psychiatry 1999 
  May;156(5):710-5.
  
• Stoll AL, Severus E, Freeman MP, Reuter S. Zboyan HA, Diamond E, Cress KK, Marangell LB.  Omega-3 fatty acids in bipolar disorder. Arch Gen Psyciatry 1999 56:407-412.     
  
• Callahan AM, Marangell LB, Ketter TA. Evaluating the clinical significance of drug interactions: 
  a systematic approach. Harv Rev Psychiatry 1996 Sep-Oct;4(3):153-8. 
  
• Marangell LB, George MS, Callahan AM, Ketter TA, Pazzaglia PJ, L'Herrou TA, Leverich GS, Post RM. Effects of intrathecal thyrotropin-releasing hormone (TRH) in refractory depressed patients. Arch Gen. Psych, 1997; (54): 214-22. 
  
• Callahan AM, Frye MA, Marangell LB, George MS, Ketter TA, L'Herrou T, Post RM. Comparative antidepressant effects between parenteral and intrathecal thyrotropin releasing hormone: Confounding effects of tolerance and implications for therapeutics. Biological Psychiatry, 1997; 41:264-272.    
  
• Marangell LB, Ketter TA, George MS. Pazzaglia PJ, Callahan AM, Pritikh P, Andreason PJ, Horwitz B, Herskovitch P, Post RM. Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. American Journal of Psychiatry, 1997; 154(2):224-230.